Also known as “secretagogues”, peptides are natural secretagogues of growth hormone. They stimulate the pituitary gland in the brain to pulsate and release natural growth hormone, but with different mechanisms. As we age, our growth hormone production slows down. This process is known as “somatopause”. With the help of these secretagogues, you can stimulate the brain’s production to release just about the same amount of growth hormone produced in your early twenties.
Growth hormone controls the reproduction and development of every cellular function in the human body. This makes it invaluable for our health as we age. It is known as the “fountain of youth” or “master” hormone. When we enter deep sleep or “REM” sleep, the pituitary gland releases a surge of growth hormone into the body. By administering one of these peptides, you are drastically increasing and taping into your natural production. Now, you might be confused as to which peptide to administer, but no need to worry because All of this will be determined in detail by one of our Hormone Replacement Therapy physicians and based on your blood work results.
Thanks to the advancement of optimization medicine, we finally have the biotechnology to extend our lives and use biotechnology to reverse or control the effects of aging. Through peptides, we give the body the ability to do what it did well when we were younger and give it that chance to do it well as we age. Peptides aren’t about cheating the health code or enhancing performance, they are about repairing and restoring our bodies. Every aspect of our bodies and our health can be completely changed by peptides.
We are at the forefront and cutting edge technology of the peptide society. We know it is the future of medicine, and we want to make sure we are forefront of this movement. Peptides have literally zero side effects and a ton of benefits. We recently attended the International Peptide Society Conference and had the pleasure of meeting and speaking to Dr. William Seeds, who is the founder of the Peptide Society Conference . Check out the video of Michael Bertonatti at the conference!
The following is a rundown of our peptide treatments program. Peptide treatments are part of our human growth hormone “HGH” secretagogue regimen. We understand this is an important step for you and that the results you may have heard about or seen with your own eyes can be very enticing, as they should be! Our human growth hormone “HGH” protocols can make a world of difference in your livelihood!
Although not required, we encourage all of our patients to educate themselves on all parts of our regimens in order to make the most accurate and conscious decision for your lifestyle.
A protein that consists of 28 amino acids. Thymosin Alpha-1 has been found to improve cell-mediated immunity in humans. Thymosin Alpha-1 plays a vital role in the control of immunity, tolerance, and inflammation. It manages immune response via an initial action on the cells of the innate immune system and thus acts as an endogenous regulator of both inflammatory and adaptive immune responses. Thymosin alpha-1’s immunomodulatory activities are centered primarily on the augmentation of T-cell function. Thymosin Alpha-1 has been used to treat diseases: Immune dysfunction, hepatitis B virus (HBV), hepatitis C virus (HCV), certain types of cancers, arthritis, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), chronic fatigue, lyme’s disease, HIV/AIDS, and autoimmune diseases.
Tesamorelin is a small molecule that stimulates the brain to produce growth hormone. Tesamorelin is a growth hormone-releasing hormone analog that increases IGF-1 levels in men and women, by an average of 181 micrograms/liter. This is by far the BEST & MOST EFFECTIVE peptide we’ve ever worked with. It binds to and stimulates GHRH receptors with similar potency as endogenous GHRH. It has a host of other benefits including nootropic effects and reducing triglycerides. Tesamorelin has subsequently been shown to decrease carotid intima-media thickness, visceral adipose tissue (VAT), and c-reactive protein (CRP). It has not been linked to significantly affect other pituitary hormones and their respective mechanisms in the body. Additionally, it can improve cognitive function for healthy seniors and patients with an increased risk of Alzheimer’s disease, due to mild cognitive impairment. Here is a study about the benefits of Tesamorelin by the National Center for Biotechnology Information (NCBI)
5-Amino-1MQ is a small, selective membrane-permeable molecule that is an inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that plays a role in cellular metabolism and energy homeostasis. This NNMT inhibitor is being used to prevent adipogenesis (fat accumulation), type II diabetes, and reversing diet-induced obesity as a result of increased intracellular NAD + and SAM. As fat cells grow larger, they begin to overproduce an enzyme called NNMT (nicotinamide N-methyltransferase). This enzyme acts to slow down fat cell metabolism (fat burning). This slowdown makes it harder for these cells to burn accumulating fat. As fat tissue grows and more NNMT is produced, higher amounts of hormones and pro-inflammatory signals are produced that are responsible for weight gain and other chronic diseases such as type 2 diabetes and cardiovascular disease. The molecule 5-amino-1MQ blocks this metabolic slowdown in white fat cells caused by excess NNMT. By blocking this metabolic slowdown, it increases the metabolism within the white fat cells. By inhibiting the NNMT enzyme, we can increase fat cell metabolism and reduce the size of white fat deposits. We lose weight because we are treating the root cause of obesity and related metabolic disease. Here is a study about the benefits of 5-Amino 1MQ by PubMed Central (PMC)
Also known as Ibutamoren, it is a growth hormone secretagogue clinically shown to increase growth hormone and IGF-1 levels significantly. It is safe to use because it doesn’t suppress the body’s natural ability to produce growth hormone. The term secretagogue refers to any substance that triggers secretion of another substance. In this case, the substance being secreted is growth hormone. Its main benefits in our biochemistry are increased muscle growth, decrease body fat and improve cognitive function. In addition, Ibutamoren helps you sleep better, speeds up recovery, and slows aging down.
IGF-1 LR3 (eighty-three amino acids) Is a polypepetide hormone structurally similar to insulin. It is central to the somatotropic axis, acting downstream of growth hormone (GH). It activates both the mitogen-activated protein (MAP) kinase and PI3K signaling pathways, acting in almost every tissue of the body. It is is most often used to stimulate muscle growth, and the compound significantly helps to make the body more sensitive to insulin, which in turn mobilizes fat for use as energy in adipose tissue. In lean tissue mass, IGF-1 LR3 prevents insulin from transporting glucose across cell membranes. As a result, the cells have to switch to burning off fat as a source of energy. Here is a study about the benefits of IGF-1 LR3 by PubMed Central (PMC)
AOD 9604 (Anti-Obesity Drug FDA Approved)Is a modified form of growth hormone which is a peptide originally used as an anti-obesity drug. It is among the peptides that have won the FDA’s approval. AOD 9604 is a well-known peptide for fat loss. It has been proven to have a robust fat burning capacity, without creating a desire to overeat. It activates degradation and fat burning (oxidation) by a method that doesn’t use the growth hormone receptor. It reduces abdominal fat stores by stimulating lipolysis (the breakdown of fat) and inhibiting lipogenesis (the transformation of nonfat food materials into body fat). It has demonstrated regenerative properties associated with growth hormone to have favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157. Last, AOD 9604 doesn’t affect blood sugar or tissue growth, and making it one of the safest peptides to take. Here is a study about the benefits of AOD by the The Journal of Clinical Endocrinology and Metabolism Journal
It starts working in as little as two weeks. By your third week, your blood sugar levels may already be starting to go down. If you see a difference, that’s great news! Studies have shown that it helps lower blood sugar in as soon as two weeks. Here is a study about the benefits of Liraglutide by the National Center for Biotechnology Information (NCBI)
CJC 1295 is a tetrasubstituted 30-amino acid peptide hormone, primarily functioning as a growth hormone-releasing hormone (GHRH) analog. CJC 1295 has been shown to increase growth hormone in enormous amounts, but without side effects. CJC 1295 stimulates growth hormone secretion and will keep a steady increase of HGH and IGF-1 with no increase in prolactin. This leads to fat loss, and increased protein synthesis thereby promoting growth hormone. One of the reasons CJC 1295 may be prescribed over traditional GHRH or HGH is its ability to bioconjugate with serum albumin, thus increasing its half-life and potential therapeutic window. It accomplishes this by using protecting groups around the amino acids of GHRH typically susceptible to enzymatic degradation. Here is a study about the benefits of CJC 1295 by the National Institutes of Health (NIH)
Ipamorelin is a selective GH-Secretagogue and ghrelin receptor agonist. The potency of ghrelin stimulation can be compared to GHRP6 with less appetite stimulation properties. However, unlike other growth hormone-secretagogues, this pentapeptide doesn’t release the same volumes of cortisol, acetylcholine, prolactin, and aldosterone. It is, for this reason, considered the first & best selective growth hormone-secretagogue. Here is a study about the benefits of Ipamorelin by PubMed Central (PMC)
Most often, IGF-1 LR3 (eighty-three amino acids) is used to stimulate muscle growth, and the compound significantly helps to make the body more sensitive to insulin, which in turn mobilizes fat for use as energy in adipose tissue. In lean tissue mass, IGF-1 LR3 prevents insulin from transporting glucose across cell membranes. As a result, the cells have to switch to burning off fat as a source of energy.
MK-677, also known as Ibutamoren, it is a growth hormone secretagogue clinically shown to increase growth hormone and IGF-1 levels significantly. It is safe to use because it doesn’t suppress the body’s natural ability to produce growth hormone. The term secretagogue refers to any substance that triggers secretion of another substance. In this case, the substance being secreted is growth hormone. Its main benefits in our biochemistry are increased muscle growth, decrease body fat and improve cognitive function. In addition, Ibutamoren helps you sleep better, speeds up recovery, and slows aging down. Here is a study about the benefits of MK-677 by PubMed Central (PMC)
Sermorelin is a secretagogue of growth hormone made of 29 amino acids. It stimulates the brain’s hypothalamus. The human hypothalamus is a gland in the brain adjacent to the pituitary gland. The pituitary gland releases the actual growth hormone into your body. As we get older, the growth hormone produced by the anterior pituitary begins to deplete. It has now been shown that Sermorelin can restore growth hormone to a youthful level causing an array of health benefits. Here is a study about the benefits of Sermorelin by PubMed Central (PMC)
Peptide MOTS-C Is a 16-amino acid peptide encoded by mitochondrial DNA. It promotes metabolic homeostasis, reduces obesity, improves insulin resistance, increases cellular respiration. Mitochondria are organelles that act like a digestive system which takes in nutrients, breaks them down, and creates energy-rich molecules for the cell. The biochemical processes of the cell are known as cellular respiration. Mitochondria are known to develop ATP aka “energy.” This peptide is excellent for weight loss, diabetes reversal, and maximize exercise performance. Overall, it will protect against age-dependent and diet-induced insulin resistance as well as diet-induced obesity. Here is a study about the benefits of MOTS-C by the National Center for Biotechnology Information (NCBI)
FGL sparks synaptic plasticity, boosting memory and learning. In addition to its effects on neurodegenerative disease, it also has been viewed as a targeted treatment for TBI, stroke, depression, and general improvement of cognitive function. Here is a study about the benefits of FGL by the National Institutes of Health (NIH)
has been shown to improve the formation/storage of memory, learning process, and brain performance. Selank is also used as a treatment for depression, anti-anxiety, immune improvement, and gastric protection. Here is a study about the benefits of Selank by PubMed Central (PMC)
is a nooptropic and a small peptide that has been developed by researchers from Washington State University to potently improve certain cognitive function of potential trauma-based brain disorders and neurodegenerative conditions such as Alzheimer’s through increased synaptogenesis. Dihexa is a peptide variant derived from angiotensin IV which has been found to improve cognitive function and diseases such as Alzheimer’s. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF “brain-derived neurotrophic factors.” It could help in the repair of the brain and nerves in neurological disease. Brain-derived neurotrophic factor (BDNF) serves as an essential regulatory mechanism in the growth and development of neurons in many areas of the brain. It has also been reported to play a part in improving the survival of neurons by heightening the resistance to nerve damage. Synaptogenesis is the formation of synapses between neurons in the nervous system. Although it occurs throughout a healthy persons’ lifespan, an explosion of synapse formation occurs during early brain development, known as exuberant synaptogenesis. Dihexa kind of mimics that response in our system. Here is a study about the benefits of Dihexa by PubMed Central (PMC)
is used as a nootropic or cognitive enhancer. It has been shown to enhance memory performance, accelerated learning, increase in BDNF, and reduce the harmful effects of stress. Doctors prescribe it for many conditions like anxiety, memory improvement, ischemic events, stroke, nerve regeneration, ADHD, opioid withdrawal, and even chronic diseases such as ALS, Parkinson’s, and Alzheimer’s.This peptide works significantly better in combination to the Selank peptide. Here is a study about the benefits of Semax by PubMed Central (PMC)
Cerebrolysin Is a mixture of peptides and has been proven to have neurotrophic action similar to nerve growth factors, which cause peripheral and central neuronal stimulation. In other words, Cerebrolysin can improve cognitive function in older people with memory problems and in those with schizophrenia. Also, it improves efficiency within the brain’s aerobic metabolic processes and improves intracellular peptide synthesis. This peptide is recommended to do once a year for 30 days. Here is a study about the benefits of Cerebrolysin by PubMed Central (PMC)
Epithalon (also known as Epitalon or Epithalone) is a polypeptide which is naturally produced in humans and has been shown to lengthen telomeres in human cells by activating the production of telomerase. In other words, if you want to ultimately slow down aging, then this is the peptide for you. Additionally, it restores and normalizes melatonin levels in older patients who have some loss in pineal function due to aging. This peptide is recommended to do once a year for 80 days. Here is a study about the benefits of Cerebrolysin by PubMed Central (PMC)
Melanotan I and Melanotan II are both analogs of the peptide hormone alpha-melanocyte- stimulating hormone (α-MSH) that induces skin tanning and is used as a cognitive anti-inflammatory remedy to protect the brain from battering aging. Like its predecessor, Melanotan I, MT2 plays a role in stimulating melanogenesis and thus provides a protective mechanism against UV rays since under its actions melanocytes are able to increase production and secretion of the hormone melanin. Scientists have also noticed that Melanotan 2 had a positive effect on libido due to its aphrodisiac properties. Additionally, Melanotan 2 exhibits a mild positive fat-mobilizing effect. Melanotan I is an FDA approved drug under the brand name Scenesse. Scenesse is most commonly used to treat patients that have an intolerance to light. Here is a study about the benefits of Melanotan by PubMed Central (PMC) –
BPC-157 has demonstrated to accelerate the healing of many different wounds, including tendon-to-bone healing and superior healing of damaged ligaments. This peptide (composed of fifteen amino acids) is also shown to decrease pain in damaged areas. Those who suffer from discomfort due to muscle sprains, tears and damage may benefit from treatment with this peptide. It can also help aid skin burns to heal at a faster rate and increase blood flow to damaged tissues. Here is one of the many study about the benefits of BPC-157 by PubMed Central (PMC)
Thymosin Beta 4 is a hormone, and its primary function is to stimulate the production of T-cells, which are an essential part of the immune and used mainly for acute injuries, and surgical repair. Here is one of the many study about the benefits of Thymosin Beta 4 by PubMed Central (PMC)
PT-141, unlike Viagra and other related PDE5 inhibitor medications, this peptide medication does not act upon the vascular system but directly increases sexual desire via the nervous system. It treats sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). Here is an FDA study and approval of the sexual benefits of PT-141 peptide
Oxytocin is a neuropeptide and hormone produced in the brain by the hypothalamus. It is often referred to as the “cuddle hormone” or the “love hormone”. Oxytocin promotes feelings of devotion, trust, and bonding and is released through physical touches, such as hugs, and also linked to the intensity of orgasms during sexual activity. Here is a study about the benefits of Oxytocin by PubMed Central (PMC)
Based on studies, long-term intranasal oxytocin improved sexual function and symptoms of depression. Oxytocin increases the intensity of orgasm, and contentment after sexual intercourse more so in men than women. For females, this neuropeptide is responsible for inducing labor contractions in pregnant women and stimulates the production of milk during breastfeeding. Oxytocin is stored in the posterior pituitary, where it can be released when needed.
(DSIP) or also known as delta sleep-inducing peptide, it is a peptide that produces a deep state of sleep. It was primarily involved in sleep regulation due to its ability to induce slow-wave sleep and can normalize blood pressure and myocardial contraction. We suggest taking this peptide five nights a week and two nights off a week to avoid a diminishing response for sleep because of its high attrition rate. Here is a study about the benefits of DSIP by PubMed Central (PMC) – Click here
Thymosin Alpha-1 is a protein that consists of 28 amino acids. Thymosin Alpha-1 has been clinically shown to improve cell-mediated immunity in humans. Recently, this peptide has been clinically proven to reduce the mortality of severe COVID-19 victims (68%) by restoration of lymphocytopenia and reversion of exhausted T cells.
Thymosin Alpha-1 plays a vital role in the control of immunity, tolerance, and inflammation. It manages immune response via an initial action on the cells of the innate immune system and thus acts as an endogenous regulator of both inflammatory and adaptive immune responses. Thymosin alpha-1’s immunomodulatory activities are centered primarily on the augmentation of T-cell function. Thymosin Alpha-1 has been used to treat diseases: Immune dysfunction, hepatitis B virus (HBV), hepatitis C virus (HCV), certain types of cancers, arthritis, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), chronic fatigue, lyme’s disease, HIV/AIDS, and autoimmune diseases. Here is a study about the outstanding auto immune defense benefits of Thymosin Alpha 1 by the Clinical Infectious Diseases Journal – Click here
Scientific studies and peer-reviewed articles
The Journal of Clinical Endocrinology & Metabolism – It is the world’s leading peer-reviewed journal for the dissemination of original research as it relates to the clinical practice of endocrinology, diabetes, and metabolism.
(JAMA) Journal of American Medical Association – It is the largest and most prestigious journal.
New England Journal of Medicine – It is a weekly national and international medical journal and one of the most recognized journals.
Mayo Clinic – It is an American nonprofit academic medical center based in Rochester, Minnesota, focused on integrated patient care, education, and research.
Pubmed – It is a free search engine with a database of references on biomedical topics.
The American Journal of Medicine – It is a peer-reviewed medical journal and the official journal of the alliance for academic Internal Medicine.
American Association of endocrinology – It is a professional community of physicians specializing in endocrinology, diabetes, and metabolism committed to enhancing the ability of its members to provide the highest quality of patient care. One of their studies showed that Testosterone levels less than 350 increase a male’s chance of cardiovascular disease.
Clinical Infectious Diseases journal – It is a peer-reviewed medical journal published by Oxford University Press covering research on the pathogenesis, clinical investigation, medical microbiology, diagnosis, immune mechanisms, and treatment of diseases caused by infectious agents.
The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine, a branch of the National Institutes of Health.
The Infectious Diseases Society of America (IDSA) is a medical association representing physicians, scientists and other health care professionals who specialize in infectious diseases. It was founded in 1963 and is based in Arlington, Virginia
National Institutes of Health (NIH): The National Institutes of Health (NIH) is an important U.S. health agency. It is devoted to medical research. Administratively under the Department of Health and Human Services (HHS), the NIH consists of 20-some separate Institutes and Centers.
With our personalized peptide secretagogue therapies, our patients report an improvement in many or all of these areas over time.
During peptide treatment, peptides are injected into the body fat, subcutaneously. This is done using the smallest needle available, similar to what a person with diabetes uses to inject insulin. Injections are initially prescribed to inject every night and over time, are decreased in frequency. However, this will be assessed by one of our medical directors.
Yes and no. 5 out of 10 patients experience side effects like uncontrollable hunger pangs, hot flashes, sleepiness, and headaches with GHRP’S. The other five, report significant better results with the combination of Sermorelin & GHRP peptides.
Peptides, like HGH, is excreted from the body very quickly so it must be injected on a nightly basis. The benefits can be seen as early as eight weeks into the peptide treatment. But initial and almost immediate benefits include better sleep, mental sharpness, and memory retention. However, to experience complete physical effects, these medications during peptide treatment should be taken continuously for six months.
Yes and no. Once optimal growth hormone levels are achieved, they can be sustained for a long time after final injection. We’ve only seen this, if weight resistance training and a healthy diet are implemented along with the patient’s peptide treatment.
For those who are not as active or lucky, once results are achieved, patients are then switched to a maintenance protocol. Thus, eliminating the need for ongoing nightly injections and reducing the total cost of therapy. However, this will be determined through follow-up blood work and the patient’s feedback during peptide treatment.
No. In comparison to injectable Human Growth Hormone / HGH, peptides are safer, more affordable, and can be just as effective. Our endocrine system can safely regulate (through a negative feedback loop) the amount of growth hormone released by the pituitary gland. This results in zero overload to the system, increased safety and prevention of side effects. You cannot overdose from peptide treatments.
Although they work on different sites in the body, Human Growth Hormone / HGH acts on the liver . Conversely, peptides act on the pituitary and/or hypothalamus gland, the amount of each needed to be effective is approximately the same.