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MK-677 ibutamoren

Ibutamoren – Also known as Ibutamoren Mesylate or MK-677



MK-677 ibutamoren


AKA MK-677

MK-677 promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1 (IGF-1) levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR (growth hormone secretagogue receptor), stimulates growth hormone release from the brain. GHSR are found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition. Therefore, we can expect that ibutamoren may also affect these functions.

A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones such as prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin. For example, cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.



MK-677 is orally active and can be taken once a day, and these are all the benefits compared to other growth hormone stimulators.

  • Increase lean body mass
  • Reduces body fat
  • Increases basal metabolic rate (BMR)
  • Prevents muscle wasting
  • Increase nitrogen levels in the body
  • Increases bone density
  • Improves sleep quality and REM (rapid eye movement) sleep duration
  • Increase overall longevity
  • Increases cognitive performance.
  • Improves memory and learning retention
  • Increases wound healing and tissue regeneration


Side Effects of MK-677 (Ibutamoren)

Although most studies report little or no side effects, the most frequent side effects of ibutamoren are an increase in appetite and transient, mild lower extremity edema and muscle pain. As an anabolic, ibutamoren should be avoided if you have cancer. Both growth hormone and IGF-1 may promote cancer growth.We would not suggest taking ibutamoren if you are Th1 dominant since growth hormone has immune stimulatory properties.T h1 cells are involved in what is called “cell-mediated” immunity, which usually deals with infections by viruses and certain bacteria.



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Need further reading?  Visit our Hormone Replacement Therapy page.




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